Wednesday’s ACC college basketball schedule includes top teams in play. Among those games is the Michigan State Spartans playing the North Carolina Tar Heels, and we have picks against the spread in this article for all the matchups.

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ACC Picks ATS Today

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Pick: Louisville +2.5 vs. Indiana

• Matchup: Louisville Cardinals vs. Indiana Hoosiers
• Projected Favorite & Spread: Indiana by 1 points (Bet on BetMGM)
• Spread: Indiana -2.5
• Time: 12:00 PM ET
• Date: November 27
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Pick: Virginia Tech +4.5 vs. South Carolina

• Matchup: Virginia Tech Hokies vs. South Carolina Gamecocks
• Projected Favorite & Spread: South Carolina by 3.3 points (Bet on BetMGM)
• Spread: South Carolina -4.5
• Time: 6:00 PM ET
• Date: November 27
• TV Channel: Fox Sports 1
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Pick: Cornell +8.5 vs. Syracuse

• Matchup: Cornell Big Red at Syracuse Orange
• Projected Favorite & Spread: Syracuse by 1.7 points (Bet on BetMGM)
• Spread: Syracuse -8.5
• Time: 7:00 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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Pick: Charleston Southern +18.5 vs. Georgia Tech

• Matchup: Charleston Southern Buccaneers at Georgia Tech Yellow Jackets
• Projected Favorite & Spread: Georgia Tech by 14.5 points (Bet on BetMGM)
• Spread: Georgia Tech -18.5
• Time: 7:30 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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Pick: North Carolina -4.5 vs. Michigan State

• Matchup: Michigan State Spartans vs. North Carolina Tar Heels
• Projected Favorite & Spread: North Carolina by 5 points (Bet on BetMGM)
• Spread: North Carolina -4.5
• Time: 9:30 PM ET
• Date: November 27
• TV Channel: ESPN2

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Pick: Cal -19.5 vs. Mercyhurst

• Matchup: Mercyhurst Lakers at California Golden Bears
• Projected Favorite & Spread: Cal by 23.4 points (Bet on BetMGM)
• Spread: Cal -19.5
• Time: 10:00 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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Pick: Notre Dame +15.5 vs. Houston

• Matchup: Notre Dame Fighting Irish vs. Houston Cougars
• Projected Favorite & Spread: Houston by 12 points (Bet on BetMGM)
• Spread: Houston -15.5
• Time: 12:30 AM ET
• Date: November 28
• TV Channel: TBS
• Live Stream: Max

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