There are 96 Football Bowl Subdivision matchups on the Week 1 card, with Akron vs. Ohio State among the best bets in terms of the over/under, according to our projections. For more tips, including parlay possibilities, see below.

See insights and computer predictions for that matchup and more below.

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College Football Computer Picks – Best Spread Bets

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Pick: Troy -9.5 vs. Nevada

• Matchup: Nevada Wolf Pack at Troy Trojans
• Projected Winner & Margin: Troy by 34.7 points
• Time: 7:00 PM ET
• Date: August 31
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Pick: James Madison -6.5 vs. Charlotte

• Matchup: James Madison Dukes at Charlotte 49ers
• Projected Winner & Margin: James Madison by 28.4 points
• Time: 8:00 PM ET
• Date: August 31
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ohio +17.5 vs. Syracuse

• Matchup: Ohio Bobcats at Syracuse Orange
• Projected Winner & Margin: Ohio by 4.4 points
• Time: 3:30 PM ET
• Date: August 31
• TV Channel: ACC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: South Alabama -5.5 vs. North Texas

• Matchup: North Texas Mean Green at South Alabama Jaguars
• Projected Winner & Margin: South Alabama by 19.5 points
• Time: 5:00 PM ET
• Date: August 31
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Pick: Notre Dame +3 vs. Texas A&M

• Matchup: Notre Dame Fighting Irish at Texas A&M Aggies
• Projected Winner & Margin: Notre Dame by 9.4 points
• Time: 7:30 PM ET
• Date: August 31
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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College Football Computer Picks – Best Total Bets

Under 58.5 – Akron vs. Ohio State

• Matchup: Akron Zips at Ohio State Buckeyes
• Projected Total: 43 points
• Time: 3:30 PM ET
• Date: August 31
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Over 63.5 – LSU vs. USC

• Matchup: LSU Tigers at USC Trojans
• Projected Total: 74.5 points
• Time: 7:30 PM ET
• Date: September 1
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 46.5 – Notre Dame vs. Texas A&M

• Matchup: Notre Dame Fighting Irish at Texas A&M Aggies
• Projected Total: 55.4 points
• Time: 7:30 PM ET
• Date: August 31
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 50.5 – Southern Miss vs. Kentucky

• Matchup: Southern Miss Golden Eagles at Kentucky Wildcats
• Projected Total: 57.6 points
• Time: 7:45 PM ET
• Date: August 31
• TV Channel: SEC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 55.5 – UCLA vs. Hawaii

• Matchup: UCLA Bruins at Hawaii Rainbow Warriors
• Projected Total: 48.5 points
• Time: 7:30 PM ET
• Date: August 31
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Take advantage of our picks and place your bet at BetMGM today!

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